Gabapentin Withdrawal

gabapentin bottle sitting on a shelf with other prescription drug medications

Gabapentin is a generic treatment for seizures and nerve pain. Gabapentin can also treat migraines, pain and fibromyalgia. Gabapentin is available as the brand-name drug Neurontin, and the number of prescriptions written for this anticonvulsant significantly increased in recent years. One reason gabapentin prescriptions increased is because of tightening opioid regulations. Doctors are turning to gabapentin as a pain treatment alternative to opioids. However, gabapentin has misuse potential. Along with misuse, gabapentin dependence and gabapentin withdrawal can develop as well.

According to reports from the Drug Enforcement Administration (DEA), the use of gabapentin increased and more than double the number of prescriptions were written in 2017 as in 2011. Additionally, a survey of people using drugs in Kentucky showed that 15 percent also used gabapentin to get high, up 165% from the year before.

How Gabapentin Works

How does gabapentin work? Gabapentin may affect someone’s brain and central nervous system. Doctors and researchers think that it stabilizes the electrical activity in the brain, and impacts how messages go from the nerves to the brain.

More specifically, gabapentin may increase the effects of, or make more, gamma-aminobutyric acid (GABA). This neurotransmitter blocks impulses between the nerves in the brain. Someone with a deficiency of GABA may be more likely to have anxiety and mood disorders, chronic pain and epilepsy.

Gabapentin Withdrawal Symptoms

Someone is more likely to experience gabapentin withdrawal symptoms if they use the drug with other substances. With someone using only gabapentin and taking it as prescribed, the risk of gabapentin withdrawal symptoms is lower, but still possible.

Gabapentin withdrawal symptoms can include:

  • Sweating
  • Gastrointestinal disturbances
  • Tremors
  • Rapid heart rate
  • High blood pressure
  • Sleep disturbances

Factors that influence whether someone will experience gabapentin withdrawal symptoms include:

  • The average dose someone used
  • How long someone used gabapentin
  • Any other medical or mental health conditions
  • The use of other substances

If someone has certain conditions and they stop using gabapentin, symptoms of these conditions may return or worsen. For example, if someone takes gabapentin for pain and they stop taking the drug, their pain may return or intensify.

Gabapentin Withdrawal Timeline

The gabapentin withdrawal timeline is different for everyone. Generally, the timeline follows this outline:

  • Within 12 hours after someone uses their last dose of gabapentin, mild withdrawal symptoms may occur
  • Anywhere from 12 to 48 hours after the last use of gabapentin, withdrawal symptoms, including anxiety, insomnia and fatigue, may develop. Heart palpitations and sweating may occur as well.
  • By day three the gabapentin withdrawal timeline might include symptoms like confusion, agitation and restlessness, as well as ongoing anxiety
  • Symptoms may continue for around five days and may start to include high blood pressure and changes in mental status
  • Within 7 to 10 days most people will start to feel better

Detoxing from Gabapentin

Preparing to detox from gabapentin can be overwhelming, particularly if you may be at risk for complications or you’re detoxing from multiple substances at the same time. To learn more about medical gabapentin detox programs or addiction treatment programs, contact The Recovery Village today. With the help of a professional addiction treatment center, like The Recovery Village, patients can start their recovery with a strong foundation for sustained success.


Ghelani, R. “Gabapentin: uses, dose, side effects and warnings.” Netdoctor, March 3, 2017. Accessed March 20, 2019.

Medical Disclaimer: Orlando Recovery Center aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.